Institute of Aquaculture

My main current research interests are corticosteroid signalling in fish, particularly with respect to osmoregulation and the stress response, and ABC transporters, especially regarding their relevance as factors modifying toxicity of environmental contaminants and as potential drug resistance genes in parasites.

In my PhD thesis, carried out at the UFZ centre for Environmental Research in Leipzig, Germany, I have studied different biochemical biomarkers of pollution in fish and fish cell cultures. Before joining the Institute of Aquaculture in September 2006, I have worked as postdoctoral researcher in France (Joint Research Unit for Fish Physiology, Biodiversity and the Environment SCRIBE, Institute National de la Recherche Agronomique, Rennes) and the UK (King’s College London).

Selected Publications

Sturm A, Colliar L, Leaver MJ & Bury N (in press) Molecular determinants of hormone sensitivity of transactivation in rainbow trout glucocorticoid receptors 1 and 2. Mol Cell Endocrinol.

Kiilerich P, Milla S, Sturm A, Valotaire C, Chevolleau S, Giton F, Terrien X, Fiet J, Fostier A, Debrauwer L, Prunet P. (in press) Implication of the mineralocorticoid axis in rainbow trout osmoregulation 1 during salinity acclimation. J Endocrinol.

Colliar L, Sturm A & Leaver MJ 2010 Tributyltin is a potent inhibitor of piscine peroxisome proliferator-activated receptor a and b. Comp Biochem Physiol C,153: 168-173.

Sturm A, Bron JE, Green DM & Bury NR 2010 Mapping of AF1 transactivation domains in duplicated rainbow trout glucocorticoid receptors. J Mol Endocrinol, 45 391-404.

Sturm A., Cunningham P, Dean M. 2009. The ABC transporter gene family of Daphnia pulex. BMC Genomics, 10:170.

Becker H, Sturm A, Schirmer K, Bury N. 2008. The A/B domain of the teleost glucocorticoid receptors determines a partial nuclear localization in the absence of hormone. Endocrinology, 149:4567-4576.

Stolte EH, Nabuurs SB, Bury NR, Sturm A, Flik G, Savelkoul HFJ, Kemenade B. 2008. Stress and innate immunity in carp: Corticosteroid receptors and pro-inflammatory cytokines. Mol Immunol, 46:70-79.

Stolte EH, de Mazon AF, Leon KM, Jesiak M, Bury NR, Sturm A, Savelkoul HFJ, Verburg van Kemenade BML, Flik G. 2008. Corticosteroid receptors involved in stress regulation in common carp, Cyprinus carpio. J Endocrinol, 198:403-417.

Bury NR, Chung MJ, Sturm A, Walker PA, Hogstrand C. 2008. Cortisol stimulates the zinc signaling pathway and expression of metallothioneins and ZnT1 in rainbow trout gill epithelial cells. Am J Physiol Regul Integr Comp Physiol, 294:R623-629.

Sturm, A., Radau, T., Hahn, T. Schulz, R. 2007. Inhibition of rainbow trout acetylcholinesterase by aqueous and suspended particle-associated organophopsphorous insecticides. Chemosphere, 68:605-12.

Sturm A., Segner H. 2005. P-glycoproteins and xenobiotic efflux transport in fish. In: Mommsen TP, Moon TW (eds) Biochemistry and Molecular Biology of Fishes, Volume 6. Elsevier, Amsterdam, The Netherlands, pp 495-533.

Sturm A., Bury, N.R., Dengreville, L, Fagart, J., Flouriot, G., Rafestin-Oblin, M-E., Prunet, P. 2005. 11-deoxycorticosterone is a potent agonist of the rainbow trout (Oncorhynchus mykiss) mineralocorticoid receptor. Endocrinology, 146: 47-55.

Bury, N.R., Sturm, A., Le Rouzic, P., Lethimonier, C., Ducouret, B., Guiguen, Y., Robinson-Rechavi, M., Laudet, V., Rafestin-Oblin, M.E., Prunet, P. 2003. Evidence for two distinct functional glucocorticoid receptors in teleost fish. J Mol Endocrinol 31, 141-156.

Sturm, A., Ziemann, C., Hirsch-Ernst, K.I., Segner, H. 2001. Expression and functional activity of P-glycoprotein in cultured hepatocytes from Oncorhynchus mykiss. Am J Physiol Regul Integr Comp Physiol, 281:R1119-26.

Sturm, A., Cravedi, J.-P., Perdu, E., Baradat, M., Segner, H. 2001. Effects of prochloraz and nonylphenol diethoxylate on hepatic biotransformation enzymes in trout: a comparative in vitro / in vivo assessment using cultured hepatocytes. Aquat Toxicol, 53: 229-245.

Sturm, A., Wogram, J., Segner, H., Liess, M. 2000. Different sensitivity to organophosphates of acetylcholinesterase and butyrylcholinesterase from three-spined stickleback (Gasterosteus aculeatus): Application in biomonitoring. Environ Toxicol Chem, 19: 1607-1615.